Methylmalonic Acid Test: Purpose, Procedure, and Results.
Methylmalonic acid is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to an inherited disorder called methylmalonic aciduria which makes the body unable to process certain proteins and lipids properly due to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA. There are a variety of different biochemical and.
A Methylmalonic Acid (MMA) Blood test is most often used to aid in the diagnosis of Vitamin B12 deficiency. Methylmalonic Acid production is linked to the body's Vitamin B12 level. When B12 levels drop, more MMA is produced. An MMA test is one of the earliest indicators of Vitamin B12 deficiency. Methylmalonic Acid testing is typically ordered when a person is suspected of having low Vitamin.
If you’ve been ordered to have a methylmalonic blood test, then your doctor wants to know what the levels of Vitamin B12 and Folate are in your body. Vitamin B12, which may also be called cobalamin, and folic acid are two essential nutrients that play a role in your health. They are important to the creation of red blood cells and making your DNA and RNA more efficient at building cells.
EVIDENCE-BASED ANSWER. The best way to evaluate a low-normal B 12 level is to check serum methylmalonic acid and homocysteine levels 1 (strength of recommendation (SOR): B, based on consistent level 2 or 3 studies).Give 1 or 2 mg of oral vitamin B 12 a day if levels are marginally low and either methylmalonic acid or both methylmalonic acid and homocysteine are elevated (SOR: A).
Urine organic acid analysis reveals large amounts of methylmalonic acid, methylcitrate, propionic acid, and 3-hydroxypropionic acid in mutase deficiency and cblA and cblB disease. Serum amino acids sometimes demonstrate elevation of glycine. When elevated serum or urine methylmalonic acid is identified, it is critical to obtain a total plasma homocysteine as a specific test to assess for.
Methylmalonic Acid Test. Overview. A metabolic disorder results when an enzyme responsible for the breakdown of our food is defective which results in compounds, also known as metabolites, accumulating in blood or urine. Incorrect metabolism means your body might have too much or too little of a metabolite which can have detrimental impacts on normal growth and development. Category.
Low Methylmalonic Acid by: Kerri Knox, RN- The Immune Queen! A low methylmalonic acid means that you have normal B12 levels, or you are taking Vitamin B12. It's meaningless and to continue taking MMA tests when you are on B12, and is a waste of time and money. Not sure why your doctor would be doing repeat MMA tests when you are on Vitamin B12.